Biomolecular condensates in plant immunity
Huang & Dong, Cell Host & Microbe, 2025
Selected publications
The science that got us here.
Peer-reviewed research from Upstream's scientific founders and collaborators spanning plant immunity, translational control, stress response, and crop resilience.
Publication archive
Foundational research and recent advances.
Translational Regulation of Plant Stress Responses: Mechanisms, Pathways, and Applications in Bioengineering
Xiang & Dong, Annual Review of Phytopathology, 2025
H₂O₂ sulfenylates CHE, linking local infection to the establishment of systemic acquired resistance
Cao et al., Science, 2024
Next-generation mapping of the salicylic acid signaling hub and transcriptional cascade
Powers et al., Molecular Plant, 2024
m6A modification plays an integral role in mRNA stability and translation during pattern-triggered immunity
Chen, Greene, Motley et al., PNAS, 2024
NPR1, a key immune regulator for plant survival under biotic and abiotic stresses
Zavaliev & Dong, Molecular Cell, 2024
Pervasive downstream RNA hairpins dynamically dictate start-codon selection
Xiang et al., Nature, 2023
Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein
Chen, Xu, Mou, Greene et al., Cell Host & Microbe, 2023
Sustaining plant immunity in rising temperature
Hua & Dong, Cell Research, 2022
PABP/purine-rich motif as an initiation module for cap-independent translation in pattern-triggered immunity
Wang, Zhang, Greene, Xu & Dong, Cell, 2022
Structural basis of NPR1 in activating plant immunity
Kumar et al., Nature, 2022
Protective plant immune responses are elicited by bacterial outer membrane vesicles
McMillan et al., Cell Reports, 2021
Plant Immune Mechanisms: From Reductionistic to Holistic Points of View
Zhang, Coaker, Zhou & Dong, Molecular Plant, 2020
Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response
Zavaliev et al., Cell, 2020
Structural basis of salicylic acid perception by Arabidopsis NPR proteins
Wang et al., Nature, 2020
Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity
Yoo, Greene, Yuan et al., Molecular Plant, 2020
To grow and to defend
Greene & Dong, Science, 2018
Global translational reprogramming is a fundamental layer of immune regulation in plants
Xu, Greene, Yoo et al., Nature, 2017
uORF-mediated translation allows engineered plant disease resistance without fitness costs
Xu et al., Nature, 2017
Salicylic Acid Receptors Activate Jasmonic Acid Signaling Through a Non-Canonical Pathway to Promote Effector-Triggered Immunity
Liu et al., Nature Communications, 2016
Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity
Gu et al., Cell, 2016
Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses
Saleh et al., Cell Host & Microbe, 2015
Redox Rhythm Reinforces the Circadian Clock to Gate Immune Response
Zhou et al., Nature, 2015
Salicylic Acid Activates DNA Damage Responses to Potentiate Plant Immunity
Yan & Dong, Molecular Cell, 2013
NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants
Fu et al., Nature, 2012
How do plants achieve immunity? Defence without specialized immune cells
Spoel & Dong, Nature Reviews Immunology, 2012
The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition
Pajerowska-Mukhtar et al., Current Biology, 2012
Timing of plant immune responses by a central circadian regulator
Wang et al., Nature, 2011
Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity
Spoel et al., Cell, 2009
Plant immunity requires conformational changes of NPR1 via S-nitrosylation and thioredoxins
Tada et al., Science, 2008
Induction of protein secretory pathway is required for systemic acquired resistance
Wang, Weaver, Kesarwani & Dong, Science, 2005
Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes
Mou, Fan & Dong, Cell, 2003
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